The aim of the Test of Rapamycin in Aging Dogs (TRIAD) Cohort is to conduct a double-blind, placebo-controlled clinical trial of a drug called rapamycin (more about this in a future post). Researchers at the University of Washington's Dog Aging Project gave rapamycin … Researcher Matt Kaeberlein is spearheading a project to test the drug rapamycin’s effects on boosting longevity in dogs. Although the media attention has been focused on the rapamycin component of the project, Kaeberlein is equally excited about the longitudinal study of aging. Rapamycin significantly improved heart function —in particular, left ventricular function during the 10 week study, and that the improvement was greatest in those patients with more severe heart disease. The Dog Aging Project has high hopes that the drug rapamycin can extend a dog's healthy lifespan by slowing down the aging process. Can I volunteer my dog for the program, and how do I do that? Dog Safety and Side Effects of Rapamycin Treatment The first phase of The Dog Aging Project’s rapamycin study was aimed at ensuring that the drug was safe for dogs. The drug being tested is called rapamycin. The Longitudinal Study … With rapamycin proving difficult to formulate into an intravenous drug for clinical trials, the project was shut down. As noted here by the Life Extension Advocacy Foundation, the Dog Aging Project researchers are moving ahead with a large study of companion animals. Although the media attention has been focused on the rapamycin component of the project, Kaeberlein is equally excited about the longitudinal study of aging. The goal of the project is to understand how genes, lifestyle, and environment influence ageing. The Dog Aging Project Rapamycin as a Potential Aging Modulator in Dogs Aging Cognitive decline Immune system decline Type 2 diabetes Autoimmune disease Alzheimer’s disease Cancer We are optimistic about the results from the Rapamycin trial, and either way are happy to be contributing to the greater good as citizen scientists! Neuroscience. The Dog Aging Project's rapamycin trial will test the effects of the drug on subjects' cognitive function, heart function, immunity and cancer incidence. CSU cardiologist Dr. Brian Scansen is collaborating with the Dog Aging Project as part of the rapamycin clinical trial. Anyone can nominate their dog to participate in either the Longitudinal Study of Aging or the Rapamycin Intervention Trials through the Dog Aging Project website at www.dogagingproject.com. Matt Kaeberlein and Daniel Promislow, the lead researchers of the Dog Aging Project, say the drug rapamycin works on a cellular level to sense the environment and determine whether it’s a … The goal of the Dog Aging Project is to understand how genes, lifestyle, and environment influence aging. Can I volunteer my dog for the program, and how do I do that? The Dog Aging Project is a citizen science endeavor, ... 13 Halloran J, et al. Everyone who loves a dog wants the animal, whether pet or work companion, to enjoy as many years as possible. “Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice”. The project included a randomized control test of rapamycin in middle-aged dogs that was designed to monitor safety over a range of doses. The recently completed introductory phase of the study, following 24 pet dogs for 10 weeks of high or low dose rapamycin treatment , suggests that we may have little to be concerned about. (CSU photo) HOW LONG DO THE BENEFITS OF RAPAMYCIN LAST IN DOGS, and how can we maximize this? If any drug has performed consistently and unequivocally well in anti-aging trials, it’s rapamycin. Until we have the final word, we are recommending one month on/one or two months off unless you are helping your dog with cancer. Elmar Krenkel/Getty Images When 14th-century Spanish explorer Ponce de Leon set out on his famous sea voyage in search of the Fountain of Youth, he landed on the shores of a verdant, unexplored land. An anti-aging pill for pooch Five hundred lucky pooches will also be given rapamycin, which appears to slow down aging according to various mouse studies; the hope is those results will translate to the dogs in this study. The Dog Aging Project includes research in the following areas: Genetics; Microbiology; Toxicology; Canine cognition; Age-related mobility; Cardiology; A clinical drug trial of rapamycin; Joining the Pack. Participating dogs will be given heart ultrasounds and have their blood pressure monitored at one of seven veterinary school teaching hospitals. According to the authors, these results suggest that rapamycin use in older dogs can actually reverse age-related declines in heart function. We were thrilled to learn of the Dog Aging Project and overjoyed to discover that Rascal’s age and size met the criteria for the Phase I study. To participate in the Dog Aging Project, owners nominate a dog (one per household) at the project website, DogAgingProject.org. Dogs and humans are biologically very alike. The Dog Aging Project has two components: a large-scale, longitudinal study of aging in pet dogs, and a rapamycin intervention trial. The project seeks to determine how real-world lifestyle factors (environment, food, and activity) interact with rapamycin in slowing aging in dogs. He is one of the primary scientists behind the Dog Aging Project, and the goal of that project is to conduct Rapamycin studies in middle-aged dogs. The Longitudinal Study is currently open to all breeds, ages, and sizes of dogs. Veterinarians will administer low doses of Rapamycin to middle-aged dogs to determine the effects of the drug on anti-aging… Rapamycin has been shown to increase the lifespan and delay or reverse many age-related disorders in mice. To nominate your pet for the study, please visit the Dog Aging Project’s dog registration page and complete the survey there. Rapamycin is now being tested in the Dog Aging Project —led by Matt Kaeberlein, Ph.D., and Daniel Promislow, Ph.D., at the University of Washington—to see if it achieves similar lifespan-extending results in canines as those obtained in mice. Researchers at the University of Washington’s Dog Aging Project have completed a phase one 10-week trial in which rapamycin, an FDA-approved organ-transplant and cancer drug, was administered in low doses It started to look like a more youthful heart,” said Matt Kaeberlein, co-director of the Dog Aging Project, who has presented this research at conferences but hasn’t yet published it. The Dog Aging Project has two components: a large-scale, longitudinal study of aging in pet dogs, and a rapamycin intervention trial. Anyone can nominate their dog to participate in either the Longitudinal Study of Aging or the Rapamycin Intervention Trials through the Dog Aging Project website. No answers yet, but the Dog Aging Project hopes to have answers in a few years. The National Institutes of Health believes a $23 million Dog Aging Project now underway is going to make a valuable contribution to science over the next decade. “It started to function better. The Dog Aging Project and its studies into rapamycin will help researchers to understand how dogs age and whether the process can be slowed. The Dog Aging Project is a National Institutes of Health funded project which will follow tens of thousands of companion dogs for ten years to identify the biological and environmental factors that maximise healthy longevity. They welcome the owners of all kinds of dogs to register at dogagingproject.org. Learning the whys behind the length and strength of dogs’ lifespans has become the impetus for the largest research data-gathering program of its kind, the Dog Aging Project.. The Dog Aging Project includes research in the following areas: Genetics; Microbiology; Toxicology; Canine cognition; Age-related mobility; Cardiology; A clinical drug trial of rapamycin “Aging is a complex phenomenon. ... And according to early results from the Dog Aging Project, soon to be published, the same may be true for canines. In mice, rapamycin in low doses has been shown to increase lifespan and improve the function of the brain, heart, immune system and muscles, in addition to protecting against most forms of cancer. We want to use that information to help dogs and people increase healthspan, the period of life spent free from disease. Although the project has been in its preliminary stages for a while, its full-throttle launch was announced this past November at the annual Gerontological Society of America meeting in Austin, Texas. This cohort is smaller than either the Foundation or Precision Cohorts. While much of the study is observational, a sizable cohort will be treated with the mTOR inhibitor rapamycin.Dogs are much closer to humans than mice, so it will be interesting to see what results. A secondary purpose is to determine whether rapamycin improves various measures of health in aging dogs. 2012; 223:102-113. Dr. Matt Kaeberlein’s Dog Aging Project is among the most recent trials investigating its longevity-promoting potential in mammals, but it’s also been the subject of numerous trials in mice, worms, flies and yeast. The results may have implications for human longevity. The researchers are partnering with pet owners in a large-scale trial of rapamycin in pet dogs. By Gary Greenberg. Extending healthspan in humans? They are also seeking particular ages, sizes, breeds, home locations and even occupations – herding, K9, service, mushers -- to The Aging Dog Project will treat middle-aged dogs with the FDA-approved drug rapamycin, a natural product discovered on Easter Island in the southeastern Pacific Ocean. — The Dog Aging Project Website. Researchers at the University of Washington’s Dog Aging Project gave rapamycin to 16 dogs and imaged their hearts. “The Dog Aging Project came in as an innovative approach to understand the process of aging,” said Dr. Francesca Macchiarini, chief of the biological resources branch in NIA’s Division of Aging Biology. How Rapamycin Therapy Works This might have important implications for people, too. The DAP is a 10-year, $23-million project funded by the National Institute on Aging (NIA), a part of the National Institutes of Health (NIH). The term “rescue dog” could be taken to a whole new level if exciting anti-aging research being conducted on middle-aged canines is soon applied to humans. One of the really interesting trials is the ongoing Dog Aging Project. The Dog Aging Project, a national research effort to learn how to foster healthy longevity in canines is looking to expand its pack of participants across the country.
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