Established as an inbred strain in 1969 at the National Institutes of The substrains of Wistar rats: Wistar Hannover (Han/Wistart) and Wistar Unilever (WU) rat are outbred; while Wistar Kyoto and Wistar Furth are inbred … Abstract. Cancer Inst. While the satellite groups were treated for the same duration as that for the treatment groups, but were rather kept under observation for an additional 15 days post treatment, and they were sacrificed on day 30. Although Slc:Wistar rats are used widely in biomedical research as outbred rats, close similarities in growth curves, survival rates, and immunological and biochemical phenotypes have been reported between Slc:Wistar and F344 inbred rats. Methods Animals Three-week-old Wistar male rats (Slc:Wistar, Japan SLC, Inc., Shizuoka, Japan) and t hree-week-old Wistar King A Hokkaido male rats (WKAH/HkmSlc, Japan SLC) (NBRP Rat No: 0154) were used as an outbred stock and an inbred Abstract. Taconic received stock at F10 from the NIHAnimalGenetic Resource in 1974.The rats … van den Brandt, J., Kovács, P. & Klöting, I. Metabolic features in disease-resistant as well as in spontaneously hypertensive rats and newly established obese Wistar Ottawa Karlsburg inbred rats. Inbred Rats Rat Models With more than 20 breeding facilities around the world, Charles River is the leading global supplier of standard rat models for biomedical research. [ Wistar … Some Wistar strains seem to be derived from Charles River stocks and strains are managed under the International Genetic Standardization (IGS) program, a unique program designed to manage the health 11, 184-189. Jpn. In three experiments we have studied the effects of acute administration of various doses (5, 10, 15 and 25 mg/kg) of desipramine (DMI) and two doses (0.5 and 2 mg/kg) of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5HT 1A receptor agonist, on behaviour of five inbred strains of rats in the holeboard and the forced swimming test (FST). The Wistar rats in the treatment groups received the daily dosage of 250 mg of the test substances (Ca-Alg aerogel or Na-Alg) for 15 days, and they were sacrificed on day 16. Although Slc:Wistar rats are used widely in biomedical research as outbred rats, close similarities in growth curves, survival rates, and immunological and biochemical phenotypes have been reported between Slc:Wistar and F344 inbred rats. J. Natl. Reserpine (RES) is an irreversible inhibitor of VMAT2 used to study Parkinson’s disease (PD) and screening for antiparkinsonian treatments in rodents.… International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2000. They can be obtained in large quantities of commercial procedures. osti.gov journal article: distribution and dynamics of rubidium-86 in "inbred" rat stock of the wistar race Wistar rats are more active than others like Sprague Dawley rats. Posthoc Tukey comparisons found that Lewis rats again responded more quickly than most other strains: Brown Norway (P < 0.01), Fischer (P < 0.05) and Noble (P < 0.001). We reported previously that nine genetic variations that were fixed in Slc:Wistar rats had identical genotypes in F344 rats. Forty inbred SD rats consisting of 20 each of weanling male and female weighing between 117– 264g and 82-116g respectively (at the commencement of the study) were used. Kim U., Clifton K. H., and Furth J. (1986) Length of gestation period in eight inbred strains and three outbred stocks of rats. Wistar rat is another common hybrid albino model animal. J. Cell Proliferation and Growth of Gastric Carcinoma Induced in Inbred Wistar Rats by JV-Methyl-N'-nitro-N-nitrosoguanidine1 Takanori Hattori,2BurkhardHelpap, and Peter Gedigk Department of Pathology, Fukul Medical School, Matsuoka Yoshlda-gun, Fukul 910 Japan [T. H.J, and Institute of Pathology, University of Bonn, 5300 Bonn, Federal Many subsequent strains were derived from the outbred Wistar commercial stock (e.g., Lewis, Buffalo, Wistar Kyoto). Wistar rats reproduce quickly; they give birth too many children during a short span of life. Kitano M., Hatano H., and Shisa H. (1992) Strain difference of susceptibility to 4-nitroquinoline 1-oxide- induced tongue carcinoma in rats. In addition, they did not respond to acute administration of either desipramine or 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Subjects. an inbred strain of rats, homozygous at most loci, produced by strict brother-sister inbreeding over many generations to develop animals for research with the same general genetic composition. It has the distinct honor of being the first rat stock developed to serve as a model animal. • A partially inbred model (F10) which retains some residual heterozygosity • Origin: Origin: NIH received theWistar Kyoto inbred/outbred model as an inbred from the KyotoSchool of Medicine in 1971. Why are Wistar Rats used in Research History of Wistar Rat Developement. Inbred Rats - WF/NHsd - 012. Twenty-four inbred strains, which were originated from Wistar strain, are listed in †gInbred Strains of Rats†h [3]. In the present experiment, it was studied whether or not they respond to acute and chr … Palm J. and Black G. (1971) Interrelationships of inbred rat strains with respect to Ag-B and non-Ag-B antigens. (1960) A highly inbred strain of Wistar rats yielding spontaneous mammo-somatotropic pituitary and other tumors. Inbred Rats - WKY/NHsd - 023. Differential responsiveness of inbred strains of rats to antidepressants in the forced swimming test: Are Wistar Kyoto rats an animal model of subsensitivity to antidepressants? Description Price Currency; 3-4 weeks, up to 60g approx weight: 230.20: USD: 4-5 weeks, 61-85g approx weight On the other hand, so-called†gWistar†h rats from outbred strains are available for many commercial breeders in Japan. In three experiments we have studied the effects of acute administration of various doses (5, 10, 15 and 25 mg/kg) of desipramine (DMI) and two doses (0.5 and 2 mg/kg) of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5HT1A receptor agonist, on behaviour of five inbred strains of rats in the holeboard and the forced swimming test (FST). 26 S. NakaNiShi, T. Serikawa, aND T. kuramoTo DuCrj inbred rats [3]. Hence, WKY rats are not only passive in the FST, but are also subsensitive to acute antidepressant administration. Envigo uses well-established techniques to successfully produce time mated rats, mice, hamsters, and rabbits. Although Slc:Wistar rats are used widely in biomedical research as outbred rats, close similarities in growth curves, survival rates, and immunological and biochemical phenotypes have been reported between Slc:Wistar and F344 inbred rats. Metabolic features in disease-resistant as well as in spontaneously hypertensive rats and newly established obese Wistar Ottawa Karlsburg inbred rats. Wistar rats and Syrian hamsters were fed with or without various concentrations of Chlorella pyrenoidosa contained high-fat diet (CHFD) for 2, 4 and 8 weeks prior to assay of serum lipids. Previously, we reported that Wistar–Imamichi (WI) rats are highly resistant to cadmium (Cd)-induced lethality and hepatotoxicity compared to Fischer 344 (F344) rats. KEY WORDS • hypertension • genetics • Wistar-Kyoto rats • spontaneously hypertensive rats • inbred strains I N 1963, Okamoto and Aoki1 reported from Kyoto, Japan, that they had selectively bred Wistar rats to be spontaneously hypertensive. Peters A. The new inbred WKY/lj-tf rats are heavier than either WKY/lj-cr or SHR/lj-cr, have unique allelic variants, exhibit a higher level of arterial pressure than our inbred WKY/lj-cr rats, are intermediate in HR between SHR/lj-cr and WKY/lj-cr rats, exhibit greater circadian variation especially during a high NaCl diet, and show salt sensitivity for arterial pressures. Almost all domestic pet rats and lab rats belong to a single species, the Norway rat (Rattus norvegicus).A tiny number of black rats (Rattus rattus) are also kept as pets, but as yet they are extremely rare in the pet trade.The classic definition of a species is a group of related individuals or populations which are potentially capable of interbreeding and producing fertile offspring. Abdeljalil Lahmanie, Antonio Armario. Direct evidence for a stem cell common to hematopoiesis and its in vitro microenvironment: studies on syngeneic (inbred) Wistar Furth rats Species. Animal Technology 37, 109-112. Wistar Furth rats were significantly quicker to respond than Noble (P < 0.01) and marginally quicker than Brown Norway (P ¼ 0.05) rats. rats and Wistar King A Hokkaido (WKAH) rats, an inbred strain of Wistar rats. Another set of strains were created by mating the outbred col- Eight subjects from each of six different inbred rat strains (Brown Norway, Copenhagen, Fischer, Lewis, Noble and Wistar Furth) were acquired from Charles River Laboratories (CRL), Inc. Half of the rats (four from each strain) started the experiment in July 2006, while the other half began the experiment in April 2007. Wistar rats have evolved themselves with humans; they eat equivalent food as humans. Since the testes are one of the most sensitive organs to acute Cd toxicity, we examined possible strain-related differences in Cd-induced testicular toxicity between inbred WI and F344 rats. "Rats, Inbred WF" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Wistar-Kyoto rats are reported to be very passive in the forced swimming test.
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